I am a game dev myself (not DOS), and I can tell you that the game cannot by itself cause a complete freeze of your PC. It is caused by either a hardware or a driver problem.
Some applications, as Raze mentions, such as Daemon tools, runs on driver level and can cause issues.
Since tests does not catch anything it can also be an overheating issue. Try (for testings sake) to under clock your CPU/GPU. It might fix the issue.
