Larian Studios Forums Divinity - Original Sin Divinity - Original Sin - General Does Telekinesis need to be a Spell?

No, you won't have access to all items.
You won't have access to all items unless you play through the game multiple times, since there are lots of quests and npcs where you are forced to make a choice between two rewards.

But you will definitely have all the items you need to complete the game.