Go for a badass run: Hard Mode + 2x Lone Wolf + 2x Glass Canon + no abusing seller of secrets (you're allowed to get one of each book for each character).
Or you can go go the King of Badassery run, you can add: No crafting (or ONLY crafting), No stealing run together with all of the above.
If you wanna go for the Badassiest run you should use all of the above plus you can only use items you find.
