Is this for D:OS?
You could try renaming the '..\Documents\Larian Studios' folder for the game, start the game to recreate it (adjust settings), exit and copy your latest save from the renamed folder to the newly created savegames folder.
So rename which folder exactly? I deleted the game from steam and reinstalled it, but the problem still persists. I have no idea what has caused this. I have a long list of about 15 saves and if for example I click to load on one near the bottom of the list, it just shoots right up to the top one. I have tried the game on my laptop via steam and it still works fine.