If all you care about is becoming indestructible, then take lone wolf.
If you care about dealing damage, then don't take lone wolf.

Lone wolf parties deal way less damage, since they're effectively trading an entire other character for a measly 2AP per turn.
The 80% increase to HP, and the extra Ability points can definitely wind up making the characters tankier, but this will not be an issue for you at endgame regardless.

That said, I'm currently running with a lone wolf because I wanted to cut down on my party size (and test a potential exploit later on).