I'm running the game at lowest detail at 1280x800 at 5-10FPS on 2.53Ghz C2D, Nvida 9400M 256mb, 8GB Ram, 512GB SSD, win 7 64Bit. So I think you'll be fine.
Low detail still looks good, the interface doesn't always register my clicks and companions sometimes glide to catch up at my FPS but as the combat is turn based the low frame rate really isn't an issue. I've put about 50 hours in now since the game release.