The pixel hunting aspect of CERTAIN button puzzles was extremely annoying to me as well.. but to me there are only 4 puzzles that were absolutely horrible in my opinion.
1) The end-game, sorry, the entire temple, every single part of it. Was this not target group tested? Because this temple sucked. The solution to get through was convoluted and testing your new theory required endless walking.... and this entire temple sucks even more if you play with 3 or 2 chars.
2) Bellegars maze, The dog/cheese/fish puzzle. Random puzzles are never fun, ever. I solved by pure luck (the game was duplicating bones and fishes meaning I couldn't tell where to even switch to what animal...
3) The blood puzzle (the room where you fight a bunch of heavy hitting demons) with the 4 buttons at the corners. Just.. UGH
4) Brazier to the hidden entrance. Sorry, but in a game where every brazier is clickable, making this one brazier do something when you turn it OFF is bad design ;P
Generally speaking, I didn't much like the puzzles but the real problem is the design of the puzzles and the clutter and lack of clear visual hints... oh well