If you load a save and leave the area immediately (go to the End of Time, etc) does it still crash?
Did you previously load any of these saves and play without issues? Or were they all made during the same play session?
Try browsing to the '..\Documents\Larian Studios' folder and renaming the 'Divinity Original Sin' subfolder.
This folder contains the saved games, configuration files and a level cache folder. Deleting or renaming it will get the game to recreate it on startup; playing the game from a different Windows user account would effectively do the same thing.
After that, start D:OS, create a new profile and exit. Copy a couple of your latest saves from the renamed folder into the newly created profile's savegames folder, and see if you have the same issue. If that works, move the rest of the games over.
If that also crashes, delete the new D:OS My Documents folder, and rename the original back again.
If that doesn't help, please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the
D:OS support tool (for the PC version). The report will contain system and game information, any crash dumps, and your saved games. If file size is an issue, any saves not related to the problem can be deleted (so keep your most recent working save, the oldest that crashes and your most recent save, and perhaps a few others in between).