Oh man, OS/2! Was so proud when i was finally able to afford 8MB RAM to get Warp 3 run smoothly...
Anyway, unless you need to play games on release day, Linux with wine is sufficient for most modern RPGs. D:OS certainly works fine with wine 1.7.24.
wine is not an viable option. it's a bad workaround at best. updates will constantly break games. performance and quality is often much worse. many effects are not supported yet and probably never will be. it might not be true for dos NOW but it's true for many titles out there that worked and then suddenly stopped working.