While playing D:OS, these issues struck me:
Gold isn't party-based: very annoying when making repairs, since everyone needs some gold, or one characters needs to get all the equipment that needs to be repaired.
Switching between characters while trading cancels the offer: annoying when skimming through inventories.
Switching between characters and comparing items, still only makes the equipment of the talk-initiating character pop up for comparison. Again, this makes trading a bother.
Gold offered should allow you to type the exact amount instead of using the slider. Faster & more accurate.

None of these are gamebreaking, but they are a severe annoyance.