Just make sure to craft your swords with maximum damage, instead using those from loot.
Been there, done that (CS 5). A 2 handed self crafted sword at character level 17, sharpened, tenebrium and tormented soul added, was only marginally better than sword of planets, boosted the same way. And the margin (out of memory - max. + 20% damage output) is, if speed of character is good, even not high enough to outweigh the third swing of the one hander (at 9 AP per round or at 7 - mid game). If total raw damage output per round is counted, the fact that a two hander costs 4 AP instead of 3 has to be factored in.
I do admit that very, very early a two hander might be preferable. But that covers a very small window between level 4, when you venture out of Cyseal, and level 7/8 when you clear the map east. And I said "might" - even there I prefer the 20 or 25% the shield offers in additional protection. Combine with a good rapier (2 AP per round) or the legendary club that is a guaranteed find (forgot the name).
Regards,
Thorsten
