What exactly were you doing and where are you? Re-loading a lot should not have caused this problem (it can eventually sometimes turn the mini-map blue/green and then crash the game the next time you try to load or save).
If the game thinks it is in the middle of a cut scene, it will disable saving and pop up a message after ten minutes. I have not seen your error message mentioned before, though. Try loading a saved game and not talking to anyone (go kill some monsters, or something) then if you do not get an error after awhile, save under a unique name and talk to a different NPC.
This unlikely the problem, but try deleting all of the files in the '..\Divine Divinity\Run\Dynamic' folder.
This folder is used as a cache for the game. Files are created / copied there from the save game folder when you load, and written / copied from that folder when you save a game. The files will be re-created as required the next time you start Divinity. If there was a corrupt file in that folder, deleting the files should fix the problem.
