It's true that you can reduce the chance of this happening by paying very close attention, but you can deal with almost any UI issue in that way, it doesn't make it good UI.
You can tell me that with careful stepping i can avoid the pit trap in the hallway of my house, and it's true, but that doesn't mean that it's not a terrible thing to have a pit trap in your house.
I've seen reams of threads on the net begging, *begging* Larian for static hitboxes. The second issue is just plain terrible. When you mouse over an interface button, it shouldn't matter what state you are in, clicking a button should click the button.
I'm an RPG veteran and have been playing them since Eye of the Beholder. I cannot remember ever being so frustrated by a simple interface problem as I am with Original Sin. It's such a spoiler on a terrific game.