turnbased is boring!!
my suggestion: advanced point and click, where when you click on the monster's legs you'll do a swing to the legs with yer sword if you click on the belly you will stab, doing different ways of damage.
With magic for example a low level freeze spell will only freeze the limb you clicked.
I'd like to see you aim that in the height of combat! Perhaps like in MechWarrior where you press a key-pad number, each representing a different part of the body, and all your attacks are aimed there.
What about a dis-arm option (I mean the weapon, not the flesh, but that would be good too)?
