Sure, some items are hand-placed. Like Clobbering Time, as you mentioned. Or the Stone Sword at the church. (Or the Cyseal Pie in one of the graves in the cemetery ) The problem is, we were talking about quality loot. Which they are not.
And it was never about saving and reloading having an effect on the game or not. It was about too much randomness and too many stupid items being generated by it.