So I've come up with a couple of things to alleviate the repetitiveness of multiple playthroughs.

An item that if "active" makes any creature that attacks you instantly die (wasn't able to figure out how to make it usable and targeted, but this works)

An item that provides an instant level up

An item that allows you to teleport to a bunch of different waypoints.

Here we go with test run #3423489234!