Personally I'm looking for more varition on loot stats, but more consistent overall quality of loot, and much less of it. Bosses should always drop rares/legendaries, and magical items should in general be rarer so they're worth more. I'd also like +skill stats like +sneak or +lore to be much rarer so that they're exciting to find instead of basically a given.
I don't see them nixing loot RNG entirely because random loot can sometimes support alternative builds that manual placement of items can't always predict. What if someone wants to build a sort of swashbuckler and needs +strength and +dex, but that combination of stats is nonexistant or really rare in manually placed loot because the developers didn't anticipate that build?
I do want more unique items as well, though, including items with actually unique stats. Most of the unique items in game felt really generic.