I have the same issue with a similar gaming setup - Windows 10 Pro, 64b, fairly high-end gaming machine. I just started re-playing, and don't remember having any trouble with my old Win 7 machine (may even be older than that, I don't remember when I first bought the game). The best workaround I have found is to hotkey the quicksave, and hit it every time I am about to go through a door or to another area. It seems to happen less when I do that, in fact, it's pretty rare now when it gets stuck if I do that every time. It does seem more pronounced in the beginning of the game in the Broken Valley village.
