I disagree completely. (With the premise of the thread). DOS was absolutely oriented towards multiplayer. That was... the core foundation of the entire game. Hell, I'd call it the number 1 selling point. That's why Larian is focusing so heavily on the multiplayer component when talking with the media (they did the same thing back in 2013).
I don't think there's any real cause for concern, as DOS demonstrated Larian to be perfectly capable of crafting a game that offered fantastic experience both with and without a co-op partner.