In the live stream they discussed if they want to have karma or not.

My thoughts:
I have written somewhere in this forum:
"Dialogue should never be a mini game. Not for perks (like D:OS1), not for influence on companions (like NWN2, KotoR2) and not for alignment (KotoR1+2)"
In these cases people feel pushed to select one extreme and stick to it. It is best if you simply stick to "choice and consequence".
In case of the D:OS2 demo it means: Gwynne does not hate you because you have bad karma. She hates you because you stole the soul of her brother, then you killed her mother and stole her soul as well.

So I am against karma, at least if it is done in a very simple good/evil or order/choas axis.