Especially in the Enhanced Edition, that will depend on the difficulty setting. You will definitely do better thinking about your approach than spamming attacks (especially since there is friendly fire).
For D:OS, combat was challenging, but with good character builds could become easy in the second half of the game. Combat and the skill system were adjusted for the EE, and a harder difficulty mode added (with changes to enemy placement, composition and AI).
So basically with the highest difficulty you will have to use different skills and positioning does become important?
