1. I went to the cave north of Hunter's Edge 2. I encountered mushrooms which are immune to elemental damage. 3. I casted Soulsap (Witchcraft) on one of the mushrooms. 4. I hit that mushroom with fire damage (fire surface). 5. The game crashed while trying to handle neverending loop of fire damage and poison-healing.
It's probably caused by mushrooms' ability to create a poisonous cloud, which heals it, and then immediately catches on fire dealing further damage. The whole process is caused by Soulsap which lowers elemental resistances of the target.