This error may be an indication of a hardware problem.
Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls have caused conflicts (generally on loading screens) and overlays from graphics tweaking/monitoring programs or chat programs have also caused issues.
Check for updated graphics drivers and Windows updates in general.
Try verifying local files: in the Steam library, right click on Divinity Original Sin Enhanced Edition and select Properties, switch to the Local Files tab and then click on the 'Verify Integrity of Game Cache...' button.
With the GOG version, in the (optional) Galaxy client, select Divinity: Original Sin Enhanced Edition in the left column, then click on the More button, and in the Manage menu select 'Verify / Repair'.
In the graphics options, try switching the Quality Preset to Low or Very Low, and see if that makes a difference. You could also try a lower game resolution or switching to the Windowed display mode.
Try disabling texture streaming (that is the main cause of reloading textures). This can improve performance, but also increases memory usage, so could cause stability issues on systems with less than 4GB RAM. It might cause a crash on startup, but it is easy to change back if it does.
Open the graphicSettings.lsx configuration file (in the '..\Documents\Larian Studios\Divinity Original Sin Enhanced Edition' folder) in Wordpad, or other text editor, and search for the term 'Stream'; two lines below that, change the one to a zero to disable texture streaming.
<node id="ConfigEntry">
<attribute id="MapKey" value="TextureStreamingEnabled" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1" type="4" />
</node>
If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might give a little more information than the error message?
- click Start (or WinKey-R), then type "event viewer" into the search box. in Windows 10, 'event' should bring up 'View event logs'.
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error (maybe sort by Date and Time) for the game
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."
