Originally Posted by Raze
Unfortunately, the Random game lock-ups on Macs with old Nvidia cards is an OSX issue, and must be fixed by Apple. They have not provided any feedback about this specifically, but the next OSX update is primarily focused on fixes.

My brother has a MBP affected by this issue, and noticed that the latest OSX El Capitan update he'd installed includes NVidia driver updates*, so tried DOS:EE again, and was able to play 'normally' - in inverted commas because he hasn't been able to play at all, so just wandered around the first level and killed some skeletons, and was able to do this and quit the game without experiencing a lockup.

Perhaps others could test more thoroughly and report if it is really fixed?

* http://www.tonymacx86.com/os-x-updates/187001-os-x-10-11-4-update.html