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Crafted and sharpened axes (preferably the crit ones) have almost double the dmg of any other weapon that you may drop.

Get blacksmith 5 and craft 5, scientist talent, 2 points on each, get rest from equip. (only 6 ability points spended max)

Iron ore on Forge > Iron Bar on Forge > Steel bar on Anvil > Axe. (If you got an Axe with crit % skip the reforge part.)

Reforge: Put axe on forge to get Steel Bar, put steel bar on Anvil to forge axe again, until you get the best axe (crit %)

Ok now you have 2 axes with crit %... (If you prefer 2h weapons, fuse 2 Iron/Steel on a Big Bar and do the same)

Don't stop yet, Put this axe on the Grinder, this will increase its damage (a lot).

Now to crafting, change equips to get crafting 5 if needed. Put 1 Tortured Soul on each axe, now put 1 essence on each (preferably not the same element so you can hit hard any enemy)

Now, IF you have tenebrium skill, put a tenebrium bar on it. (idr if this overlaps the essence, if it does, put the essence again, its possible to stack both dmgs)
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Ok you are good to go now...

(Anyone be free to add or correct me if I said something wrong)