When I examined root templates after the patch that supposedly fixed the problem last year, I noticed that they had made a lot of stuff stackable that was not stackable before and increased stack sizes for other stuff.
One patch made a change to which items were global, which made the issue of running out of handles easier to hit with a lot of trading or crafting. A subsequent patch increased the limit to 64k, but it is still possible to reach that (a couple with playtimes on the order of 350 hours, and one person trying to make a mod to have traders regenerate their inventory each time a character talked to them).
One person ran into this problem in D:OS Classic, as well, though only after it was fixed in the EE, with a playtime about 550 hours.
