I agree that isometric view is preferable for most of the game. Over-the-shoulder view would not be good for exploring the world of D:OS.
However, I definitely feel the ideal is definitely to have a mixed view. In XCOM, for example, the camera is usually isometric but it zooms in and moves occasionally to provide a close-up or over-the-shoulder view of certain actions.
I've mentioned this before -- one of the bigger weaknesses with the storytelling in D:OS is that it is not cinematic enough. I've compared it to other games before to show that the characters often do not "converse" so much as monologue. They also do not really express themselves physically.
On the topic of the camera angle, I feel that D:OS would greatly benefit from having more cinematic camera angles, particularly during dialogue. I'd much rather be looking at the 3D model than a static portrait. Even older 2D TRPGs
tried to be as cinematic as possible.
Vandal Hearts (today's obligatory example)
