I hope not, love the isometric style of original sin.
The 3d games is just to much. I got them all, and i rarely play trough em before i just get bored.
Got half way trough da:i, amalur, morrowind, skyrim, fallout4, gothic3, risen2/3, two worlds1/2, the witcher 2/3. (and about all the others)
I never finish when they are 3d, they are just to big and time consuming. (well except the mass effect ones, love those:)
On the other hand i always finish the isometric games and i just love them more. Much better to keep track of what you are doing, where you going and the ui.
Wasteland2, d:os and pillars i had several playtroughs.
That's just a completely personal opinion, even if true to an extent.
A more cinematic experience, however, does not work AGAINST isometric: rather, it enriches it.