Please give us full rebinding of keys this time. As a lefty i had to use razer synapse to rebind left ctrl to right ctrl and alt to numpad 0 in D:os1. (play with mouse in left hand and arrows keys.) So my pinky rest on numpad 0 while thumb is on right ctrl button.
That works fine for me (primary or secondary hotkey for Show world tooltips). Remap the 'Select Slot 0' hotkey to something else (Alt/Ctrl/Shift + 0 for example) if you don't want it to also trigger the first skill slot (don't just clear the secondary slot hotkey(s), or the 'missing' ones will be 'fixed' when restarting the game).