The worst is actually the slippery slope.
From getting actual directions in Morrowind (since you need to find them), to getting sloppier in Oblivion to just not bothering actually telling where to go, just tell the quest, and let the marker do the rest, in that disabling markers just gets you stuck.
See, "progress" in RPG's.
There was certainly an element of "follow the cheese wedge" in Oblivion: I can't say how much the quests relied on it because I never got out of the habit of doing it.
Then again, there was trying to find Punabi in Morrowind. While I had an entire horde of cliffracers queueing up to screech at me. For hours. I nearly threw my PC out the window in annoyance.