Two bugs found:
1) Defeated the Hound Master under the castle and he dropped a key. Saved my game and shut the game down. Loaded game up and the key is gone.

2) Markers on my map from quest npcs for awhile. At some point though I saved my game and quit the game. When I came back all my waypoints from NPCs (yellow ones) were gone.

This is a multiplayer game that I am currently playing solo.