If I know that the enemy is going to take twice as long to kill and is going to kill me twice as fast, I'm probably not going to charge its face as I may have in easier difficulties.
Except it'll be just like normal; CC-lock till you killed it.
But that has more to do with the armor mechanics than difficulty. With it however, adding more HP is just a waste that gives absolute no difficulty but more grindy killings.
