If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might help identify the cause of the crash?
- click Start (or WinKey-R), then type "event viewer" into the search box
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error (maybe sort by Date and Time) for the game
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."


Try browsing to the '..\Documents\Larian Studios' folder and deleting the 'Divinity Original Sin 2' subfolder.
This folder contains the saved games, configuration files and a level cache folder. Normally I would suggest renaming the folder for troubleshooting purposes, but if you don't have any saved games that isn't an issue.
Next, extract the replacement folder from the download below into your '..\Documents\Larian Studios' folder, and see if that will let you start the game without crashing.

https://www.dropbox.com/s/kjvq79igruaeu4h/DOS2_doc_20165341.zip?dl=0

The graphicSettings.lsx file is set to 1280x720 Windowed mode, Very Low quality preset, which you can change in the options (manually, or hit autodetect) if this gets the game to start.
If that doesn't help, you can delete the downloaded My Documents D:OS 2 folder.