There should be improvements to inventory management and AI in D:OS 2, and the tag system is different than the traits in D:OS. For difficulty, the tactician and honour modes are being planned from the start, rather than added afterward.
For the EE, aiming for the feet (when possible) can help (most of the idle animation movement is in the upper body).
For skills/spells you can use the turn order portraits at the top of the screen to target.
For normal attacks, right click an opponent and select Attack (no effect if you miss click) or hold the Shift button down to queue commands and left click: if you get a red target selection indicator, release the Shift button, otherwise if you get the white move indicator, right click to cancel while still holding Shift.
There is also a mod:
Stand Still When I Attack
