There will be another game to finish off the story arc with Damian and the Divine One, but no details have been announced (or even determined yet, as far as I know). There is another game planned after D:OS 2 based on the same engine and mechanics.
Personally, I would like to see another game using a dragon knight main character, which would pretty much have to be real time and use a third person camera (for dragon combat).
So I'm guessing by this Larian's next game will be another isometric turn based game and maybe a Dragon Knight Saga sequel will be the game after that. There's also the possibility of a Dragon Commander sequel.
Looks like a long wait unless Larian have the capacity to work on two games at the same time now that they have the extra studio.