Another Dragon Commander would be cool, but what I would really like to see is a game like Original Sin, but set during the magitek punk era of Dragon Commander.
I have always preferred more original visually distinct world scenarios in RPGs like that over the straight up familiar medieval fantasy that the majority of Divinity games and traditional CRPGs on the whole almost ubiquitously tread.
Nobody has really done anything with an original setting like Dragon Commander in turn based RPG form (outside of the Japanese) since Black Isle Studios was thrown under the bus by Interplay, and Troika Games shrived up and died more then a decade ago.
Having a Divinity RPG with an industrial revolution setting like the brilliant but forgotten Arcanum: Of Steamworks and Magick Obscura would be amazing.