+Magic/Physical Armor damage reduction isn't any different than just adding more armor, while making it less intuitive. And straight up +Armor skills aren't very interesting. We definitely need a couple defense skills, preferably one helping shields, but hopefully make it interesting. We might need bodybuilding and willpower to come back. Those aren't particularly interesting either, but they may be necessary.
Global cooldown reduction is stupidly hard to balance, as we saw in the first game. It's a cool idea, but it doesn't work well in a turn-based game (it works well in games with real-time cooldowns, though).
Constitution still gives you a way bigger return than strength or intelligence. 10 points in Con is +70% vitality, which defends against all damage, where 10 in strength is +20% physical armor, which only helps against physical damage, though it does block CC. And memory is perfect at this point, imo. Feels really nice, unlike 2 memory cost per skill before.