Even if more enemies wandered around a little bit so initial starting locations weren't so fixed for most fights that would make things a bit more dynamic. But making random spawns is quite a bit of work, especially for a NG+ mode that probably only 5% of people would play. A NG+ mode that isn't just a lame gimmick would already be boatloads of work, making sure fights are still challenging and there's some form of player progression.

Perhaps they could design some kind of area trigger where enemies would spawn within that area instead of in a precise spot (e.g., for that void insect fight or the radeka fight, enemies would spawn within a general area instead of in the exact same spot every time). Would be a nice option for modding at least.