When you restart the game and click the Profiles button in the main menu, what happens when you click on the original profile and click the Select button (or hit the Enter key)?
If you just create a new profile and then exit, do you have the same problem when you restart?
Are you shutting down all non-essential programs (especially anti-virus) before starting the game? There are anti-virus programs that have interfered with D:OS and D:OS 2 creating or accessing folders in the My Documents folder.
Try exiting out of the Steam client, and starting the game directly from the '..\SteamApps\common\Divinity Original Sin 2\bin\EoCApp.exe' program file, by right clicking and running as administrator. Does that make a difference?
