Comparing D:OS2 with Rage of Mages or Space Ranger sounds for me like you are comparing a strawberry with an apple. Both taste delicious but they are far from tasting the same. Loot is surely not a reason to replay the game. Testing out different classes or different playstyles would be the thing. One playthrough you slaughter everyone, the other you try to avoid killing at all. One time you go full mage other time full physical. You can also try it in different difficulties. Combat in Tactican will be different from combat in Classic, not much perhaps but different and harder.
Also D:OS is about exploring, not about getting told what to do. It is about figuring stuff out by yourself, not following a plan. If you are not the guy who just loves to explore and test stuff out, probably it is not the best fitting game for you. I wouldn't even call something like 'picking a locked chest up' as something 'test worthy', more like something basic if you want to prevent backtracking.
Also I don't think 'replay' value is the core concept of this game. Replayable games are mostly focused around a lot of RNG like generated dungeons. Some will replay it to test different stuff, some just will be happy to have the game finished while doing their style of playing.
