Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls have caused conflicts (generally on loading screens) and overlays from graphics tweaking/monitoring programs or chat programs have also caused issues.
Did you check for updated graphics drivers and Windows updates in general, as well as updated chipset drivers for your motherboard, etc, after installing Win 10?
Have you tried other, similarly demanding DirectX 11 games?
