After selecting your original profile (clicking or using the up and down arrow keys) does the text turn red? If clicking the Select button doesn't work reliably to switch, does hitting Enter?

Can you delete the debug profile?

Are you shutting down all non-essential programs (especially anti-virus) before starting the game?

Try (optionally) exiting out of the Steam client (if applicable), and starting the game directly from the '..\SteamApps\common\Divinity Original Sin 2\bin\EoCApp.exe' program file, by right clicking and running as administrator. Does that avoid the problem? If so, you can right click again, select properties, switch to the Compatibility tab and check the option to always run as administrator.


If that doesn't help, try browsing to the '..\Documents\Larian Studios' folder and rename the 'Divinity Original Sin 2' subfolder. This folder contains the saved games, configuration files and a level cache folder.
Next, start the game and create a new profile, then exit and copy the saves from the renamed folder to the Savegames folder for the newly created profile (doesn't matter if the name matches or not).