I must admit I'd also like to see another D2 type game, or even just more of D2: Broken Valley being one of my favourite game areas ever. Hard to say what the future holds, though I figure that, in theory, the Original Sin engine should be as capable of doing 1st/3rd person as it is isometric.
I'm mostly trying to forget Skyrim's menu system: even with mods it was utterly dreadful. FO4's isn't as bad but still needs serious improvement. I do wonder if a lot of us like what we started with, though: I know a lot of people are really fond of Morrowind's system (which D2's inventory is very similar to) but I always preferred Oblivion's. Albeit with the Darnified menus so that it didn't fill the screen with extra-large text.