I think Miss Chance should NOT be a big factor. If you are using weapons of your level and fighting enemies of your level or lower, you should stand a good chance of hitting them.
Missing in games is very frustrating, and D:OS is a tactical RPG where the difficulty is geared so that enemies can do a lot of damage and kill you quickly. I think it is better that losing a fight is based more on making poor decisions and less on getting bad dice rolls.
