So other areas are fine?
Do you have the same problem hitting Space, rather than using the button, to end the current turn?
Did you try Alt-F4 to quite the game, or Ctrl-Shift-Esc or Ctrl-Alt-Del to bring up the Task Manager?
Are you shutting down all non-essential programs (especially anti-virus) before starting the game?
If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might help identify the cause of the crash?
- click Start (or WinKey-R), then type "event viewer" into the search box. in Windows 10, 'event' should bring up 'View event logs'.
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error (maybe sort by Date and Time) for the game
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."
Please email supportdos2@larian.com, with a description (or link to this topic) and a save during combat where this occurs (or a Dropbox or Google drive link, etc).
Each save is a folder in the '..\Documents\Larian Studios\Divinity Original Sin 2\PlayerProfiles\<ProfileName>\Savegames' folder. In Windows Explorer you can zip file(s) and folder(s) by right clicking on it/them and selecting 'Send To | Compressed (zipped) Folder'.