So even deleting the Debug_Client_Profile_1 profile folder doesn't get the game to switch to one of the other profiles on startup?
Try browsing to the '..\Documents\Larian Studios' folder and rename the 'Divinity Original Sin 2' subfolder.
That will get the game to recreate it on startup, and you should be prompted to create a new profile, after which you can exit and move the saves from your original profile's savegames folder to the newly created one.
If that doesn't help, try doing a clean boot and then test the game. Click Start, or hit WinKey-R, type in msconfig and hit enter; in the General tab, click Selective Startup, uncheck Load startup items (if required) and leave Load system services and Use original boot configuration options checked. Next, Click on the Services tab, check the box to Hide all Microsoft services, then click the Disable All button (maybe make a note of which are currently enabled/disabled), then click OK and reboot the computer.
Run msconfig again to switch back to the normal boot configuration.
