Lol, just pretend that lizards shed in this world :P As far as its usefulness, it's hard to say whether it has too many downsides (memory and AP cost, resist reduction, AND it removes positive statuses). But a free skill that can remove every negative status needs to be tempered by something. With my mod it would remove stunned and knockdown since those don't completely eliminate your turn anymore (though unless you have 2 turns of stunned or KD, then it's mostly pointless since you won't recover the AP you've lost already).
Blind, decaying touch, shackles of pain, crippled, necrofire, or several smaller negative statuses can all be worth spending an AP to ditch. Obviously there's some strategy to consider if you have some buffs you'd rather not lose, and whether the resist reduction is worth losing the debuffs for, but that's what makes it interesting. I think I'll drop the resist reduction to 15 or 20% though. 25% is pretty harsh.
Sebille's source skill is just bad and boring, so I'm not going to compare shed skin to that.