I don't see why someone couldn't host D:OS2 on a server and leave it running all the time for people to join and leave as they wish. Player count could probably be raised to 6 or 7 or maybe more with a reworked UI. Unfortunately the host would have to control a player so there'd be an unused player slot a lot of the time
Another problem is you can't have different players in different "levels." You could have one giant level with lots of different areas though.
You probably won't be able to import characters into this either. So people dropping in would have to play whatever characters exist in the game already.
I guess I don't really see too many advantages of this approach over just hosting regular games. I suppose it allows people to play without needing the host to play.