It appears that specific skillbooks don't matter, but it's hard to tell. They combined rain with decaying touch for blood rain, Some cool things to notice in the video (tisk, tisk, Larian, you knew somebody would point these things out :P)

Necromancy will have raise dead/bone manipulation skills: one of necromancy skills they flash over is "Raise Bone Widow," with the description "Raise a walking pile of bones. It can consume corpses to restore vitality and receive a stacking damage buff." Another skill was "Bone Cage," which restores physical armor + more armor per nearby corpse.

Many skills will have higher ability requirements. We see Steam Lance has a hydrosophist requirement of 3, and the raise bone widow requires necromancy 2. This isn't much of a surprise, but good to see that confirmed.

Blood rain had a requirement of hydrosophist 1 and necromancy 1, so it appears skillcrafted skills will be hyrbrid skills.

Steam Lance had 2 turquoise lines in the upper right, which I believe represented that it took 2 source points to cast. This indicates to me that source will be much more common, even in the first act, than we've seen. This is a good thing to me, since it will be easier to balance around common use of source skills rather than making them rare.

They showed a level 19 character with 5500 vitality, and about 500 phys/magic armor. That's a pretty massive discrepancy in vitality vs. armor, though maybe there was a reason for that. Then again, the bone cage skill increased armor by 1000 + 1000 more per nearby corpse, so who knows. There was also a level 22 character with 12000 vitality, so who knows. Just kind of interesting to see what sort of scaling we might see. Good to see that elemental resists were quite low (5-15% resist mostly), so looks like that might not end up getting super inflated.