Larian Studios Forums Divinity: Original Sin 2 - The Modding Dungeon Divinity - Original Sin 2 - Modding General D:OS2 on GOG and Steam Workshop content.

Assuming DOS works like most other games, yes they will (which I assume because Larian is much more competent than say... nSpace). I'm assuming we have a mod directory or config file that the game is checking for compatibility.